P04-03. Cross-clade neutralization analysis of plasmas from clade B, C and CRF01_AE HIV-infected donors
نویسندگان
چکیده
منابع مشابه
Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains
Citation: Cheedarla N, Hemalatha B, Anangi B, Muthuramalingam K, Selvachithiram M, Sathyamurthi P, Kailasam N, Varadarajan R, Swaminathan S, Tripathy SP, Vaniambadi SK, Vadakkupattu DR and Hanna LE (2018) Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains. Front. Immunol. 9:618. doi: 10.3389/fimmu.2018.00618 ...
متن کاملB-lymphocyte dysfunction in chronic HIV-1 infection does not prevent cross-clade neutralization breadth.
Aberrant expression of regulatory receptors programmed death-1 (PD-1) and B- and T-lymphocyte attenuator (BTLA) is linked with dysregulation and exhaustion of T lymphocytes during chronic human immunodeficiency virus type 1 (HIV-1) infection; however, less is known about whether a similar process impacts B-lymphocyte function during HIV-1 infection. We reasoned that disruption of the peripheral...
متن کاملCross-clade neutralization potential of the plasma of antiretroviral naïve HIV-1 infected children from north India
Methods We recruited 38 antiretroviral naïve HIV-1 infected children after getting written informed consent from their parents/guardians. The study was approved by the institute ethics committee. Neutralization efficiency of the patients’ plasma was tested against tier 2 pseudoviruses (3 clade C ZM53, Du172.17 and Du156.12 and 3 clade B RHPA4259.7, TRO.11 and SC422661.8) obtained from NIH AIDS ...
متن کاملCross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors.
HIV variation presents an obstacle to a global AIDS vaccine. Viral diversity and host variations in MHC expression both affect vaccine responses. Whether CD8 T cells from HIV-infected donors in 1 part of the world cross-recognize isolates from other regions will provide guidance about whether country-specific vaccines are needed. We compared recognition of HIV(IIIB) and representative B' (Thai ...
متن کاملCross-neutralizing activity of human anti-V3 monoclonal antibodies derived from non-B clade HIV-1 infected individuals.
One approach to the development of an HIV vaccine is to design a protein template which can present gp120 epitopes inducing cross-neutralizing antibodies. To select a V3 sequence for immunogen design, we compared the neutralizing activities of 18 anti-V3 monoclonal antibodies (mAbs) derived from Cameroonian and Indian individuals infected with clade AG and C, respectively. It was found that V3 ...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2009
ISSN: 1742-4690
DOI: 10.1186/1742-4690-6-s3-p31